I was trusted the strange mission on finding a game my wife used to play and by her description, it was an Interactive Fiction!
All she may recall was the character trying to escape a house and having to solve many puzzles connected to math and calculus. Also, she described an interesting resource where the game designer created fake Internet pages. Using in game links, the player could access this pages which were actually on line to gather more clues to solve puzzles.
Does anyone have any idea what game she is talking about?
I don't think these are what you want, but here they are, lol:
PC/APPLE (Mac computer back then): 7th Guest and its sequel 11th Hour (these do involve trying to escape from a house and have some pretty advanced and really cool/fun puzzles --- some of them probably could use calculus... I was young when I played these on my Mac many many many years ago, lol. So, calculus was very above my ability and knowledge level, lol)
NES: Maniac Mansion (this is defintely not it, as it doesn't use advacned math puzzles, but it's still an awesome game, to this day, hehe)
NES: Shadowgate (this too is definately not it, as it doesn't involve trying to get out of a house, lol, but it's still an awesome game)